Eudēmonia Summit 2026 | West Palm Beach, Florida

Continue the Conversation in Cannabinoid Science

Stay connected with educational insights, cannabinoid research, and practical resources from Charlotte’s Web and CBD CLINIC.

Presented by:Marcel Bonn-Miller, PhD, Chief Scientific Officer, Charlotte’s Web

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  • Massage Foam Rollers
  • JAWKU Massage Gun
  • CBD CLINIC Water Bottle
  • Level 5 Stick
  • Sleep 25mg THC-Free
  • Relieve & Ease CLINIC

November 5–8, 2026

Explore the Science

Presentation recap

A Closer Look at the Endocannabinoid System

The endocannabinoid system is one of the body’s signaling networks, and it is involved in sleep, pain, stress, and memory. The talk covers what the system is and how it may change with age, the everyday levers that move it (movement, sleep, stress, and diet), what the research shows for cannabinoids in sleep, stress, and pain, and what to know about product quality, drug interactions, and dose.

What the talk covers

  1. What the endocannabinoid system is
  2. How it may change with age
  3. Everyday levers: movement, sleep, stress, and diet
  4. Cannabinoid research in sleep, stress, and pain
  5. Product quality, drug interactions, and dose
Download the presentation slides (PDF, 631 KB) (Opens in a new window)
Portrait of Marcel Bonn-Miller

Presenter

Marcel Bonn-Miller, PhD

Chief Scientific Officer, Charlotte’s Web

Dr. Marcel Bonn-Miller earned a BA in psychology and PhD in clinical psychology from the University of Vermont and completed his Postdoctoral Fellowship at Stanford University School of Medicine. He began his career at the Department of Veterans Affairs and the Department of Psychiatry at the University of Pennsylvania, where he built and directed two fully grant-funded cannabis research centers. He then transitioned to industry roles as Director of Cannabinoid Research at Zynerba Pharmaceuticals, Vice President of Human and Animal Research at Canopy Growth Corporation, and currently serves as Chief Scientific Officer at Charlotte’s Web.

Widely considered one of the early and leading research pioneers in the field of cannabis and mental health, Dr. Bonn-Miller has conducted seminal work on the interrelations between cannabis/cannabinoids and a range of health conditions, including pain, anxiety, HIV, PTSD, and sleep disorders. He brings a unique perspective to cannabinoid therapeutics, having worked in medical center and academic settings for over a decade and within industry for the past 9 years. He serves on the editorial boards of several scientific journals and has published over 175 peer-reviewed empirical publications on cannabis.

Video

What is the endocannabinoid system?

In about a minute, Marcel Bonn-Miller, PhD, introduces the endocannabinoid system and the range of processes it is involved in.

Read the transcript

[On screen: the CBD CLINIC logo above a search bar. The question “What is the endocannabinoid system?” is typed in. Marcel Bonn-Miller, PhD, is then identified on screen.]

Marcel Bonn-Miller, PhD: So the endocannabinoid system is really a system that is central for a lot of different processes in the body. A term that was coined a little while back was eat, sleep, protect, forget, relax. And those are really sort of shows the breadth of the different systems that are controlled by the endocannabinoid system.

And when it comes out of balance, then we see problems: problems sleeping, problems relaxing. The endocannabinoid system is a system that needs to remain, ideally, in homeostasis. If you do something to support it, that may only last for a short period of time.

When we think about, you know, especially with the processes eat, sleep, relax, protect, forget, these are ones that aren’t just, you know, “I need to relax today, but not tomorrow,” or “I need to sleep well tonight, but not next week.” And so really, when we think about addressing these problems, we think about long-term solutions.

[Marcel is shown in interview, intercut with footage of hemp plants and laboratory work. The video ends on the CBD CLINIC by Charlotte’s Web logo.]

Length: 1 min

From the presentation | Five things to take home

Key takeaways

Five ideas from the talk, each with the published research behind it. Open a takeaway to read the detail.

  1. 01

    What the endocannabinoid system is and why it may matter for healthy aging

    It is a body-wide signaling system: receptors, messengers the body makes on demand (anandamide and 2-AG), and enzymes that clear them. It is involved in sleep, pain, stress, and memory.

  2. 02

    How tone changes with age

    Tone is the overall level of signaling in the system. In one study of cannabis users, adults aged 55 to 71 had lower anandamide at their first blood draw than adults aged 21 to 24. In animal studies, the system helps bring the body back to balance after stress, and mice born without its main receptor showed early, age-like memory decline.

    Source
  3. 03

    Exercise, sleep, nutrition, and stress

    In studies of fit and young adults, a slow jog or moderate run raised anandamide, and several nights of short sleep led to a higher, later daily peak of 2-AG. Diet and stress can move the system too, not always in the same direction, and a rise or a fall is not good or bad by itself.

    Sources
  4. 04

    Cannabinoid products

    Weigh the evidence by product: substantial for cannabis in chronic pain, most often tested as a THC and CBD spray, and early for CBN in sleep and for cannabinoids in stress. Before anything else, check product quality (ask for a batch-specific certificate of analysis), your medications, and the dose.

    Sources
  5. 05

    Cannabinoid approaches entering healthcare

    Since April 2026, a program from the Innovation Center at the Centers for Medicare & Medicaid Services (CMS), the Substance Access Beneficiary Engagement Incentive, lets participating organizations in two Medicare models, ACO REACH and the Enhancing Oncology Model, provide eligible hemp products to eligible patients, up to $500 a year. A physician first decides that use is appropriate and documents a shared decision covering benefits, risks, and current medications. Participants in a third model, LEAD, can offer it starting January 2027. Eligible hemp products are limited to federally legal hemp and other parameters set by CMS.

Foundational science

Cannabinoid Science 101

Four points from the talk, from the body’s own signaling system to the plant compounds that act on it.

01

The system at a glance

  • Receptors are the locks (CB1, concentrated in the brain, and CB2, first found on immune cells).

  • The body’s own messengers, anandamide and 2-AG, are the keys, made on demand. In lab studies, 2-AG was far more plentiful in the brain and switched CB1 fully on, while anandamide switched it on only partway.

  • Enzymes, FAAH and MAGL, are the cleanup crew that keeps each signal brief.

Schematic of CB1 receptor sites in the body

CB1concentrated in the brain, also found elsewhere in the body

Schematic of CB2 receptor sites in the body

CB2first found on immune cells, such as those in the spleen

Schematic, not to scale. From slide 4 of the presentation.
  • 02

    Found through the plant, named after it

    Scientists found the first receptor while studying how THC, the main intoxicating compound in cannabis, works, and only then found the body’s own molecules that fit it.

  • 03

    THC, CBD, and CBN work in different ways

    Over 120 cannabinoids have been identified in cannabis. THC activates CB1, the receptor behind the high. CBD (cannabidiol) binds the two main receptors only weakly and acts on several other targets. CBN (cannabinol) binds CB1 more weakly than THC, but CB2 about as strongly.

  • 04

    Full-spectrum is not isolate

    A full-spectrum hemp extract carries CBD plus other cannabinoids, aroma compounds called terpenes, and a little THC. An isolate is CBD alone.

Mechanism at a glance

What each one is and how it acts

A mechanism-only view of the molecules in the four points above.

Molecule What it is How it acts
The body’s own messengers
2-AG2-ArachidonoylglycerolOne of the body’s own messengers, made on demand. In lab studies, far more plentiful in the brain than anandamide.
  • CB1: Switched it fully on in lab studies
AnandamideOne of the body’s own messengers, made on demand.
  • CB1: Switched it on only partway in lab studies
From the cannabis plant
THCDelta-9-tetrahydrocannabinolThe main intoxicating compound in cannabis. Scientists found the first receptor while studying how it works.
  • CB1: Activates it; CB1 is the receptor behind the high
CBDCannabidiolOne of over 120 cannabinoids identified in cannabis. A full-spectrum hemp extract carries it with other cannabinoids, terpenes, and a little THC; an isolate is CBD alone.
  • CB1 · CB2: Binds both only weakly
  • Other: Acts on several other targets
CBNCannabinolOne of over 120 cannabinoids identified in cannabis.
  • CB1: Binds it more weakly than THC
  • CB2: Binds it about as strongly as THC

The body’s own messengers

  • 2-AG2-Arachidonoylglycerol

    One of the body’s own messengers, made on demand. In lab studies, far more plentiful in the brain than anandamide.

    • CB1: Switched it fully on in lab studies

  • Anandamide

    One of the body’s own messengers, made on demand.

    • CB1: Switched it on only partway in lab studies

From the cannabis plant

  • THCDelta-9-tetrahydrocannabinol

    The main intoxicating compound in cannabis. Scientists found the first receptor while studying how it works.

    • CB1: Activates it; CB1 is the receptor behind the high

  • CBDCannabidiol

    One of over 120 cannabinoids identified in cannabis. A full-spectrum hemp extract carries it with other cannabinoids, terpenes, and a little THC; an isolate is CBD alone.

    • CB1 · CB2: Binds both only weakly
    • Other: Acts on several other targets

  • CBNCannabinol

    One of over 120 cannabinoids identified in cannabis.

    • CB1: Binds it more weakly than THC
    • CB2: Binds it about as strongly as THC

Mechanisms only, summarized from the presentation. This is not a comparison of benefits, safety, or effectiveness, and it does not describe any product.

Research | Sources cited

Explore the Research

The studies behind the talk, linked to their published versions.

Sources discussed in the presentation

  1. Morris et al. (2026): Age and the endocannabinoid system (Opens in a new window)DOI: 10.1038/s41598-025-27618-1
  2. Raichlen et al. (2013): Exercise intensity and anandamide (Opens in a new window)DOI: 10.1007/s00421-012-2495-5
  3. Hanlon et al. (2016): Short sleep and 2-AG (Opens in a new window)DOI: 10.5665/sleep.5546
  4. National Academies (2017): National review of cannabis evidence (Opens in a new window)DOI: 10.17226/24625
  5. Bonn-Miller et al. (2024): Our CBN sleep trial (Opens in a new window)DOI: 10.1037/pha0000682
  6. Childs et al. (2017): THC dose and stress (Opens in a new window)DOI: 10.1016/j.drugalcdep.2017.03.030
  7. Zuardi et al. (2017): CBD dose and public-speaking anxiety (Opens in a new window)DOI: 10.3389/fphar.2017.00259
  8. Bonn-Miller et al. (2017): Labeling accuracy of CBD products sold online (Opens in a new window)DOI: 10.1001/jama.2017.11909
  9. Bansal et al. (2023): Cannabinoid-drug interactions in healthy adults (Opens in a new window)DOI: 10.1002/cpt.2973

Links open each paper’s published record. Full citations and disclosures are in the presentation slides.

Practitioner education | Downloads

Put the Science Into Practice

Explore educational resources designed to support informed, responsible cannabinoid conversations.

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Safety and quality

What makes a product clinic ready

In this short video, Marcel Bonn-Miller, PhD, discusses what published data show for CBD in healthy adults, and what makes a product clinic ready, from the science behind a formula to seed-to-shelf quality control.

From the talk. Before anything else, check product quality (ask for a batch-specific certificate of analysis), your medications, and the dose.

Read the transcript

[On screen: the CBD CLINIC logo above a search bar. The question “Is CBD safe?” is typed in. Marcel Bonn-Miller, PhD, is then identified on screen.]

Marcel Bonn-Miller, PhD: The conclusion from all the data independently analyzed was, and this is published data, in a healthy adult, CBD is pretty safe.

What distinguishes products that are truly clinic ready versus not is how rooted in the science they are. If a product is developed science forward, based off of our understanding of the literature, and it’s linked to a specific outcome, the reason these ingredients are in there, the dose that is conveyed to the patient or consumer in terms of how much to use of it, that is a product I would say that’s clinic ready.

So seed to shelf control really matters, because we have traceability from the minute the seed goes into the ground until the package goes out of the warehouse for shipping. We have quality controls along that entire process.

[Marcel is shown in interview, intercut with footage of laboratory testing, manufacturing, and packing. The video ends on the CBD CLINIC by Charlotte’s Web logo.]

Length: 1 min

CBD CLINIC | Product overview

The CBD CLINIC Collection

CBD CLINIC™ offers practitioner-focused cannabinoid formulations developed to support integrative care. The portfolio includes OTC topical products formulated with FDA-recognized active ingredients for the temporary relief of minor muscle and joint aches, alongside ingestible dietary supplements formulated to support sleep, stress management, recovery, and everyday wellness as part of a comprehensive care approach.

Topicals

OTC pain relief topicals and massage creams

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    Level 5 Pain Relief Ointment is a maximum strength topical with menthol (16%) and camphor (11%) that delivers targeted cooling and warming sensations to support the temporary relief of minor muscle and joint aches and pains.

    Format
    Ointment
  • Level 5 Pain Relief StickActive ingredients:Menthol 16% / Camphor 11% Details

    Level 5 Pain Relief Stick supports the temporary relief of minor muscle and joint aches and pains with FDA-recognized OTC active ingredients (11% camphor, 16% menthol) in a convenient, easy-to-apply glide-on stick.

    Format
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  • Level 5 Pain Relief OilActive ingredients:Camphor 15% / Menthol 5% Details

    Level 5 Pain Relief Oil is formulated to support the temporary relief of minor muscle and joint aches and pains with camphor (15%) and menthol (5%) in a massage oil format designed for broader application.

    Format
    Massage oil
  • Level 4 Pain Relief OintmentActive ingredients:Menthol 7% / Camphor 5% Details

    Level 4 Pain Relief Ointment is an extra-strength topical formula with camphor (5%) and menthol (7%) for the temporary relief of minor muscle and joint aches and pains.

    Format
    Ointment
  • Relaxing Massage CreamKey ingredients:Camphor 5% (active) / 900 mg broad-spectrum CBD per jar Details

    CBD CLINIC™ Relaxing Massage Cream combines skin-nourishing oils, and a blend of botanicals—including arnica, lavender, chamomile, and frankincense with camphor (5%) to support a calming massage experience.

    Format
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  • Soothing Massage Cream (Unscented)Active ingredient:900 mg broad-spectrum CBD per jar Details

    CBD CLINIC™ Soothing Massage Cream (Unscented) is a fragrance-free cream designed to provide gentle hydration and smooth massage application for sensitive skin.

    Format
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Ingestibles

Dietary supplements

  • Stay Asleep+ CBN GummiesCannabinoids:30 mg CBN per gummy · THC-free† Details

    Stay Asleep+ Gummies deliver 30 mg CBN in a THC-free† formula designed to support sleep continuity and promote restful sleep through the night.*

    Format
    Gummies
  • Quality Sleep Low-Dose THC GummiesCannabinoids:30 mg CBN / 2.5 mg THC per gummy Details

    Quality Sleep Gummies feature a dual-action blend of 30 mg CBN and 2.5 mg THC designed to support healthy sleep patterns and sustained rest.*

    Format
    Gummies
  • Quiet Mind Low-Dose THC GummiesCannabinoids:35 mg CBD / 1 mg THC per gummy Details

    Quiet Mind Gummies deliver 35 mg CBD with a 1 mg microdose of THC in a fast-acting formula designed to support a calm state of mind and help manage everyday stress.*

    Format
    Gummies
  • Relieve & Ease Low-Dose THC GummiesCannabinoids:15 mg CBD / 15 mg CBC / 15 mg CBG / 2.5 mg THC per gummy Details

    Relieve & Ease Gummies deliver a multi-cannabinoid blend of CBD, CBC, CBG, and THC designed to support recovery following physical activity and help ease everyday muscle soreness.*

    Format
    Gummies
  • 65mg Full-Spectrum CBD OilCannabinoids:32.5 mg CBD / approx. 1 mg THC per 0.5 mL serving Details

    65 mg CBD Oil is a full-spectrum tincture designed to support everyday wellness, relaxation, recovery, and healthy sleep cycles.*

    Format
    Tincture
    Strength
    65 mg CBD per 1 mL (full-spectrum)
  • 100mg CBD Isolate Extract OilCannabinoids:50 mg CBD per 0.5 mL serving · isolate Details

    100 mg CBD Oil is a maximum-strength, non-intoxicating tincture formulated to support daily balance and overall wellness.*

    Format
    Tincture
    Strength
    100 mg CBD per 1 mL
  • 60mg CBD Soft GelsCannabinoids:60 mg CBD / approx. 1 mg THC per soft gel Details

    60 mg CBD Soft Gels provide a measured serving of full-spectrum cannabinoids in an easy-to-take capsule for consistent daily wellness support.*

    Format
    Soft gels
    Spectrum
    Full-spectrum
View the CBD CLINIC collection

From our parent brand

Charlotte’s Web™ Ingestibles

CBD CLINIC™ is part of the Charlotte’s Web™ family. Alongside the practitioner collection above, Charlotte’s Web offers THC-free† gummies made with broad-spectrum hemp extract from USA-grown hemp. Every batch is third-party tested and comes with a Certificate of Analysis. These products are not part of the CBD CLINIC collection.

  • Sleep 25mg THC-Free CBD GummiesPer serving (2 gummies):25 mg broad-spectrum CBD / 3 mg melatonin Details

    Raspberry-flavored broad-spectrum CBD gummies with melatonin, designed to support restful sleep.*

    Format
    Gummies
    Serving size
    2 gummies
  • Calm 25mg THC-Free CBD GummiesPer serving (2 gummies):25 mg broad-spectrum CBD / 75 mg lemon balm Details

    Lemon lime-flavored broad-spectrum CBD gummies with lemon balm, designed to support relaxation.*

    Format
    Gummies
    Serving size
    2 gummies
  • Daily Recovery 25mg THC-Free CBD GummiesPer serving (2 gummies):25 mg broad-spectrum CBD / 53 mg curcuminoids (from turmeric) / 25 mg ginger Details

    Ginger-flavored broad-spectrum CBD gummies made with organic turmeric and organic ginger, designed to support recovery and healthy joints.*

    Format
    Gummies
    Serving size
    2 gummies
  • Daily Care 25mg THC-Free CBD GummiesPer serving (2 gummies):25 mg broad-spectrum CBD Details

    Mango peach-flavored broad-spectrum CBD gummies crafted for everyday balance and overall wellness.*

    Format
    Gummies
    Serving size
    2 gummies

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

†THC-free means non-detectable THC.

Partnership options

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Disclaimer

Hemp-derived products are not FDA-approved to diagnose, treat, or prevent disease.